107 papers
This systematic review and meta-analysis of nine preclinical studies demonstrates that SGLT2 inhibitors significantly improve pulmonary hemodynamics and right ventricular function in animal models of pulmonary arterial hypertension, suggesting their potential as a novel therapeutic strategy.
This study demonstrates that the ROCK inhibitor fasudil exhibits beneficial anti-inflammatory and pro-proliferative effects on human trisomy 21 neural progenitor cells, suggesting its potential as a candidate prenatal pharmacotherapy for Down syndrome.
This study demonstrates that pharmacological modulation of voltage-gated sodium channels differentially alters ON and OFF cone bipolar cell contributions to the rat ERG b-wave, revealing distinct sodium channel-mediated mechanisms in these pathways that could inform retinal stimulation strategies for degenerative conditions.
This study presents a comprehensive kinome-wide profiling of 192 diverse kinase inhibitors, revealing that polypharmacology is widespread and independent of regulatory approval, with many approved drugs exhibiting potent off-target effects on understudied kinases that complicate mechanism-of-action studies but offer opportunities for drug repurposing and toxicity prediction.
This study presents a hierarchical oral drug delivery system featuring drug-loaded polymeric nanogels encapsulated within a mucoadhesive alginate/chitosan microparticle shell, which demonstrates controlled release and a significantly extended oral half-life compared to the free drug.
Patchouli alcohol suppresses gastric cancer growth and reverses immune evasion by inhibiting the NF-κB/PD-L1 axis, which enhances CD8+ T-cell-mediated cytotoxicity both in vitro and in vivo.
This study demonstrates through computational and experimental methods that antidepressants interact with estrogen receptors, suggesting that their clinical efficacy may partly stem from modulating hormone signaling pathways in addition to their effects on monoaminergic targets.
This study demonstrates that widely circulating pyrethroid resistance mechanisms, including target site mutations and P450 over-expression, significantly reduce the efficacy of transfluthrin-based spatial emanators by diminishing both irritancy and blood-feeding inhibition in mosquitoes, thereby posing a critical risk to malaria and other vector-borne disease control efforts.
This study validates a novel, low-cost hollow fiber infection model using hemodialyzer cartridges to simulate human ganciclovir pharmacokinetics and establish the first pharmacokinetic/pharmacodynamic targets for treating cytomegalovirus (CMV) infection, thereby enabling optimized dosing strategies and resistance management.
This study demonstrates that early paroxetine exposure in developing zebrafish induces transient apoptosis and delayed neurogenesis, leading to brain remodeling and impaired social behavior, thereby providing a biological mechanism linking prenatal antidepressant use to the pathogenesis of autism spectrum disorder.
This study identifies a pharmacokinetic interaction where the sulfo-butyl ether-beta-cyclodextrin (SBECD) excipient in intravenous posaconazole reduces teicoplanin protein binding, leading to increased renal elimination and lower drug concentrations in hematopoietic stem cell transplant patients.
This study demonstrates that red yeast rice-derived monacolin K {beta}-hydroxy acid (MKA) ameliorates cardiac hypertrophy in spontaneously hypertensive rats by inhibiting the ERK1/2/c-Fos signaling pathway, offering a safe, multi-organ protective, and transgenerationally effective therapeutic strategy for hypertensive heart disease.
This study demonstrates that cancer-derived extracellular vesicles loaded with EGFRvIII siRNA via transfection achieve efficient in vitro knockdown and selective tumor homing in vivo, although this targeted delivery failed to induce significant tumor shrinkage despite successfully downregulating EGFRvIII expression.
This study demonstrates that administering inhaled nitric oxide via a portable device immediately after reperfusion significantly improves survival rates and physiological outcomes in a rat model of crush syndrome, suggesting its potential as an effective emergency intervention in disaster settings.
This systematic review and meta-analysis of 86 studies identifies a panel of 71 consistently dysregulated circulating microRNAs, with miR-21 and miR-423-5p emerging as high-quality, robust diagnostic biomarkers for heart failure, while highlighting the need for standardized protocols to address heterogeneity across species and sample types.
This study elucidates that STING agonist-induced pulmonary injury is driven by a cascade where activated endothelial cells recruit and activate NK cells and neutrophils, forming a toxic feedback loop that causes lung hemorrhage and inflammation.
This paper presents a comprehensive protocol for assessing in vivo DNA damage levels specifically in rodent testicular germ cells, including spermatids and spermatocytes, using a modified alkaline comet assay with specialized methods for cell suspension, scoring, and data curation.
This paper introduces single-cell physiologically-based pharmacokinetic (scPBPK) models that incorporate expression-dependent processes via weighting functions to simulate and analyze cellular drug concentration heterogeneity, demonstrating their utility through case studies on AZD1775 and midazolam.
Using an AI-based screening pipeline targeting the chromatin remodeling factor BAZ1A, researchers identified compound C06 as a potent and specific repressor of pathogenic DUX4 expression in facioscapulohumeral muscular dystrophy, demonstrating its viability as a therapeutic candidate despite its ability to inhibit multiple kinases.
This study reports the discovery of a novel small-molecule extracellular inhibitor of the KCa3.1 ion channel, identified through structure-based molecular dynamics simulations and virtual screening of the Molport database, which was subsequently validated experimentally via patch clamp assays.